Guangdun Peng is a Professor at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (GIBH-CAS), where he serves as Director of the Research Center for Lineage Technology and Engineering and Deputy Chief Process Engineer of the National Large-Scale Scientific Facility for Human Cell Lineage Atlas (CLAF). He received his Ph.D. in developmental biology from the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (SIBCB-CAS), and completed postdoctoral training in computational biology at the University of California, Los Angeles (UCLA). His research centers on the spatiotemporal regulatory principles governing cell fate determination during embryonic development and pathological remodeling. Prof. Peng has made seminal contributions to spatial omics technology development. He pioneered Geo-seq, one of the earliest spatial transcriptomics methods, which enabled systematic gene expression profiling in mammalian embryos with spatial resolution. He subsequently developed MISAR-seq, the first platform to simultaneously profile spatial transcriptomes and chromatin accessibility from the same tissue section, thereby establishing a unified framework for spatial multi-omics analysis. Leveraging these self-developed technologies, Prof. Peng’s laboratory has systematically dissected three-dimensional spatiotemporal fate decisions during embryogenesis, establishing a new paradigm for dynamic spatiotemporal multi-omics research. His work has generated comprehensive maps of cell lineage trajectories and uncovered the molecular logic by which spatial cues direct cell identity acquisition. In parallel, his team has revealed spatially resolved functional cellular mechanisms underlying diverse pathological conditions and developed AI-driven computational frameworks that integrate high-resolution spatial data with predictive models, achieving an integrated pipeline bridging experimental observation with in silico simulation. Prof. Peng has served as Principal Investigator on multiple major national research initiatives, including the National Key R&D Program of China and the CAS Scientific Instrument Development Program. His research has been published in leading international journals including Nature, Cell, Nature Methods, Nature Genetics, Nature Cell Biology, Developmental Cell, Nature Communications, and Science Bulletin.
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